The duo of fly-half, Rhys Patchell and tight-head, Samson Lee appear likely to miss Wales’ game against Australia in Cardiff.
Meanwhile, the match is set to take place at the Principality Stadium in Cardiff on Saturday, 10 November this year.
Wales prop, Lee is on his part in line to miss Saturday’s Test against Australia due to a hamstring injury.
While on the other hand, Outside-half, Patchell is available for the Welsh national Rugby Union team after successfully passing concussion tests.
In-spite of that, though, defence coach, Shaun Edwards insists he still has to prove his fitness for the British nation.
On Monday, Wales made a formal confirmation Cardiff Blues flanker, Ellis Jenkins was fit after recuperating from a shoulder problem.
“Ellis is looking favorable for selection but I am not sure about the other two,” Edwards made a confirmation statement.
In Lee’s absence, Wales would call on Dillon Lewis and Tomas Francis to both fight for the tight-head prop berth.
“You want all your players to be fit and available,” Edwards went on.
“I had incredible impression with Dillon Lewis at the weekend around the park as well.
“Samson is a very strong scrummager and thankfully, we have Tomas Francis fit as well.
“And we are pretty strong in that area,” the chief trainer explained.
Wales are set to be cautious over Patchell who has not played in the last four weeks, though.
And that is in the wake of picking up another head injury while playing for Scarlets against Ospreys only recently.
Wales beat Scotland 21-10 in Autumn international
Wales have done just enough to beat fellow Britons, Scotland 21-10 in the Autumn international which took place on Saturday.
The Welsh claimed the inaugural Doddie Weir Cup with the impressive victory as the Scottish’s miserable run in Cardiff continued.
Wales have now won in the last ten matches against Scotland in Cardiff, a winning streak dating back to 2002.
The Welsh national team head coach, Warren Gatland said: “We were a bit rusty at times.
“For long periods of the game, we were pretty comfortable without the ball and we defended well.
“We scored some nice tries and will be better for that but Scotland put us under a lot of pressure.” Gatland summed up.